A. Isaiah 6:2, 6 contains the only mention of them in the Bible.  It is possible that the "flying serpents" of  Isa. 14:29; 30:6 (BDB 977 I plus BDB 733) are in mind.  There is even a possibility the name comes from an Egyptian word serref ("guardian griffin").

B.  They seem to be a particular order of angels.  Their name means "burning ones" (BDB 977 II).  The word is from the root "to burn" (BDB 976).

C. In Revelation 4:8, it seems that the Seraphim and the Cherubim are combined.  "The Beasts" look like Cherubs which have two wings (Exod. 25:19) or four wings (Ezek. 1:6-14), but in Revelation they have six wings and occupy the place of Seraphim.

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